- Immediate Changes of Glucose Metabolism After Gastretomy for Early Gastric Cancer in Patients with Type 2 Diabetes
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Ki Hyun Kim, Yoon Hong Kim, Kyung Won Seo, Ki Young Yoon, Yeon Myeong Shin, Young Sik Choi, Bu Kyung Kim
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Kosin Med J. 2021;36(1):25-33. Published online June 30, 2021
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DOI: https://doi.org/10.7180/kmj.2021.36.1.25
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Abstract
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Objectives
It is well known that type 2 diabetes (T2DM) is dramatically improved after bariatric surgery, although the mechanisms have not been clearly identified. The skill required for gastric surgery for gastric cancer is very similar to that needed in bariatric surgery. In this study, we evaluated the immediate improvement of T2DM after gastrectomy for gastric cancer.
Methods
A total of nine patients who were diagnosed with early gastric cancer (EGC) and already had T2DM underwent a 75 g oral glucose tolerance test (OGTT) before surgery and within two weeks after gastrectomy. Glucose, insulin, and c-peptide were measured before, and 30 and 60 minutes after ingesting 75 g of glucose. From these trials, we calculated the HOMA-IR, insulinogenic index, Matsuda index, and area under the curve (AUC).
Results
The mean age of participants was 57.23 ± 11.08 years and eight of them were men. HOMA-IR (4.2 vs. 2.3, P = 0.012) levels were decreased after surgery. There were no significant differences of insulinogenic index, fasting blood sugar before and after surgery. The Matsuda index (3.3 vs. 8.3, P = 0.002) was significantly increased and AUC (512.9 vs. 388.7 mg-hr/dL, P > 0.001) upon 75 g OGTT was significantly decreased after surgery.
Conclusions
Insulin sensitivity was immediately improved after gastrectomy for early gastric cancer in patients with T2DM.
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- Remote health monitoring services in nursing homes
Jiwon Kim, Hyunsoo Kim, Sungil Im, Youngin Park, Hae-Young Lee, Sookyung Kwon, Youngsik Choi, Linda Sohn, Chulho Oak Kosin Medical Journal.2023; 38(1): 21. CrossRef
- Expressions of miRNAs in Papillary Thyroid Carcinoma and Their Associations with the BRAFV600E Mutation and Clinicopathological Features
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Song I Yang, Young Sik Choi
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Kosin Med J. 2020;35(1):1-14. Published online June 30, 2020
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DOI: https://doi.org/10.7180/kmj.2020.35.1.1
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1,022
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Abstract
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Objectives
The microRNAs (miRNAs) are known to be commonly expressed in papillary thyroid carcinoma. The BRAFV600E mutation is the most common genetic mutation in thyroid cancer. The main aim of this study was to determine the possible association between expression of the three miRNAs and that of BRAFV600E mutation and the clinicopathological features in papillary thyroid carcinoma.
Methods
This study was conducted on 51 paraffin-embedded tissues (42 thyroid cancer, 9 benign tumor) obtained from patients undergoing thyroidectomy at the Endocrine Center of OOO University Hospital.
Results
miRNAs expression was significantly high in patients with cervical lymph node metastasis and advanced TNM stage. In addition, miR-146b expression levels were significantly higher in papillary thyroid carcinoma patients with BRAFV600E mutation. The relative quantification (2-ΔΔCt) of miR-146b was also high among the miRNAs. Individually, the AUCs for miRNA-146b was 0.923 (cutoff value −1.97, sensitivity 88.9%, specificity 85.7%).
Conclusions
Especially, expression of miR-146b increased higher in PTC patients with BRAFV600E mutation. These findings showed a role of miR-146b as potential biomarkers in differentiating PTC from benign tumor and as a prognostic indicator of PTCs. Further investigation will need for the roles of miRNAs in the pathogenesis of papillary thyroid carcinomas.
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- Cyto-Histological Profile of MicroRNAs as Diagnostic Biomarkers in Differentiated Thyroid Carcinomas
Maria de Lurdes Matos, Mafalda Pinto, Marta Alves, Sule Canberk, Ana Gonçalves, Maria João Bugalho, Ana Luísa Papoila, Paula Soares Genes.2024; 15(3): 389. CrossRef
- Diagnostic value of BRAFV600E mutation analysis in fine needle aspiration for evaluation of thyroid nodules
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Hae Won Lee, So Young Ock, Bu Kyoung Kim, Su Kyoung Kwon, Young Sik Choi, Jeong Hoon Kim, Sang Bong Jung
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Kosin Med J. 2018;33(1):1-11. Published online January 21, 2018
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DOI: https://doi.org/10.7180/kmj.2018.33.1.1
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Abstract
PDFPubReader
- Objectives
Ultrasound-guided fine-needle aspiration (FNA) is routinely used in the evaluation of thyroid nodules. However, it has several pitfalls, as has been noted in nondiagnostic and indeterminate cases. This study aims to investigate the value of BRAFV600E mutation co-testing in FNA cytology.
MethodA total of 310 patients underwent BRAFV600E mutation co-testing in FNA cytology on thyroid nodules between June 2013 and June 2014. Of the 310 patients, 69 patients who had undergone a surgery for thyroid nodules were included in this study. The presence of the BRAFV600E mutation was determined by allele-specific polymerase chain reaction amplification of exon 15 of the BRAF gene.
ResultsOf 69 cases, 33 (47.8%) were BRAFV600E mutation positive. The BRAFV600E mutation was not significantly associated with high-risk features such as tumor size, lymph node metastasis, and pathological stage. The respective diagnostic performance of FNA (P = 0.02), BRAFV600E mutation (P = 0.03), and ultrasonographic (P = 0.00) findings was statistically significant. The sensitivity, specificity and positive predictive value of FNA was 64.9%, 83.3%, and 94.8%. The sensitivity, specificity and positive predictive value of BRAFV600E mutation was 56.1%, 91.7%, and 96.9% and the US features was 91.2%, 91.7%, and 98.1% respectively. However, sensitivity of FNA with BRAFV600E mutation (77.2%) was lower than FNA with US (92.9%) and combination all together (92.9%).
ConclusionIn this study, we found that US features were the most useful in preoperative differential diagnosis of thyroid nodules. BRAFV600E mutation co-testing in FNA cytology was also useful for diagnosis of thyroid tumors.
- Iodine nutritional status and awareness of iodine deficiency among adults, including pregnant women, in Tuguegarao, Philippines
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Young Sik Choi, Kwang-Hyuk Seok, Jong Jin Lee, Gina Jieun Hong, Pablo M. Afidchao, Bu Kyung Kim, Jee-Yeong Jeong
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Kosin Med J. 2018;33(1):64-74. Published online January 21, 2018
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DOI: https://doi.org/10.7180/kmj.2018.33.1.64
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PDFPubReader
- Objectives
Iodine deficiency causes multiple health problems. Previously we reported that 96% of high school students in Tuguegarao, Philippines had adequate iodine levels. However, iodine deficiency-associated problems remain among adults in the Philippines. Therefore, we evaluated iodine nutritional status and goiter prevalence among adults, including pregnant women, in Tuguegarao, Philippines.
MethodsA total of 245 adults, including 31 pregnant women, provided samples for urinary iodine analysis, and all pregnant women completed a questionnaire about iodine deficiency.
ResultsThe median urinary iodine level was 164.0 ± 138.4 g/L; 38.4% of the participants were iodine deficient, according to the International Council for Control of Iodine Deficiency Disorders (ICCIDD) criteria. No severe iodine deficiency was observed. Among the 31 pregnant women, 24 (77.5%) fell into the iodine deficient category defined by a stricter World Health Organization (WHO) guideline, in which iodine deficiency is considered when urinary iodine levels are below 150 g/L. Almost half (42%) of the pregnant women were unaware of the harmful effects of iodine deficiency on the human body and their fetus.
ConclusionsAlthough iodine nutritional status in the Philippines has improved, iodine deficiency still exists among adults, especially among pregnant women. Therefore, our study strongly suggests that a better strategy should be established to monitor iodine nutritional status among adults continually, and to focus on populations susceptible to iodine deficiency, including pregnant women and women of reproductive age, to achieve the total elimination of iodine deficiency.
- Obesity and Insulin Resistance According to Age in Newly Diagnosed Type 2 Diabetes Patients in Korea
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Ju Won Lee, Nam Kyu Kim, Hyun Joon Park, Jun Yeob Lee, Seon Yoon Choi, Eun Mi Lee, So Young Ock, Su Kyoung Kwon, Young Sik Choi, Bu Kyung Kim
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Kosin Med J. 2016;31(2):157-166. Published online January 20, 2016
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DOI: https://doi.org/10.7180/kmj.2016.31.2.157
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825
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Objectives
With the rapid increase in the prevalence of diabetes, the age groups of diabetic patients are becoming diversified. This study will examine the degree of obesity, insulin resistance, and insulin secretion ability among patients first diagnosed with diabetes according to age and gender.
Methods
The subjects of this study included 616 patients who were first diagnosed with diabetes during a routine physical examination. This sample was obtained from a total of 28,075 adults aged 19 years and older who received the examination among 33,829 participants in the Korea National Health & Nutrition Examination Survey (KNHANES) from 2007–2010. The subjects were categorized by age into young age (age: 19 – 39 years), middle age (age: 40 – 59 years), and old age (age: 60 years and older). The degree of obesity was categorized according to body mass index (BMI) into normal weight (BMI: 18.5 ∼ 22.9), overweight (BMI: 23 ∼ 24.9), and obesity (BMI: 25 or above). Insulin resistance was evaluated by homeostatic model assessment of insulin resistance (HOMA-IR).
Results
It was found that 14.1% (n = 87) of a total of 616 subjects (324 men, 292 women) were in the young age group, 43.8% (n = 270) were in the middle age group, and 42.1% (n = 259) were in the old age group. In addition, 83.3% of men that were overweight or obesity were in the young age group, while 79.2% and 60.5% were in the middle age and old age groups, respectively. A total of 82.2% of women that were overweight or obesity were in the young age group, while 79.5% and 77% were in the middle age and old age groups, respectively. For men, the more obesity they were in all age groups, the higher their HOMA-IR. For women, the more obesity they were in the young age and middle age groups, the higher their HOMA-IR; however, women in the old age group showed the highest HOMA-IR when they were of normal weight.
Conclusion
Among diabetic patients first diagnosed with the disease in Korea, the youth population had the highest obesity rate. Insulin resistance increases as an individual's weight increases among those patients who are first diagnosed with diabetes; the only exception noted is for elderly women.
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Citations
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- Remote health monitoring services in nursing homes
Jiwon Kim, Hyunsoo Kim, Sungil Im, Youngin Park, Hae-Young Lee, Sookyung Kwon, Youngsik Choi, Linda Sohn, Chulho Oak Kosin Medical Journal.2023; 38(1): 21. CrossRef
- Diagnostic Value of Preoperative Serum Thyroglobulin Measurement for the Diagnosis of Malignancy in Follicular or Hürthle Cell Neoplasms of the Thyroid Gland
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Nam Kyu Kim, Seong Joo Kang, Weon Hyoung Lee, Go Eun Yeo, You Jin Han, Bu Kyung Kim, Su Kyoung Kwon, Yo-Han Park, Young Sik Choi
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Kosin Med J. 2014;29(1):17-22. Published online December 17, 2014
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DOI: https://doi.org/10.7180/kmj.2014.29.1.17
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Abstract
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Objectives
The aim of this retrospective study was whether serum Tg predicts malignancy in follicular or Hürthle-cell neoplasms on fine needle aspiration.
Methods
A chart review of 111 patients (90 females, 21 males; mean age 46.8 ± 11.9 years) with follicular or Hürthle-cell neoplasms on fine needle aspiration, who were surgically treated between Sep. 2001 and Sep. 2011, was performed. Predictive factors for malignancy were identified by the chi-squared test and multivariate logistic regression.
Results
There were no differences between 41 malignant and 70 benign lesions in serum Tg or any of the normalized indexes. Receiver-operator characteristic analysis revealed no cutoff value. Lesions with serum Tg levels greater than 500 g/L had no significant difference. And also there were no independent predictors of malignancy by multivariate logistic regression.
Conclusions
In this study, the author found that serum Tg has poor accuracy for predicting malignancy in follicular or Hürthle cell neoplasms on fine needle aspiration.
- A Case of Type III Autoimmune Polyglandular Syndrome
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Sangeon Gwoo, Young Sik Choi, Bu Kyung Kim, Yo Han Park, Keun Tae Kim, Jun Seop Lee
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Kosin Med J. 2013;28(2):167-170. Published online January 19, 2013
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DOI: https://doi.org/10.7180/kmj.2013.28.2.167
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Abstract
PDFPubReader ePub
The autoimmune polyglandular syndromes (APS) are groups of syndromes comprising a combination of endocrine and nonendocrine autoimmune diseases. Among of those four types of APS, the main characteristics of the 3 APS are autoimmune thyroid diseases associated to other autoimmune diseases, excluding Addison’s disease. Type 3 APS are also subdivided into 3A, 3B, 3C, and 3D. Recently, we experience a case of APS manifesting 3A, 3C, and 3D subtype. A 28-year-old woman developed type I diabetes. According to her medical history, she had Graves’ disease, vitiligo, auimmune hemolytic anemia and systemic lupus erythematosus (SLE). The antoantibodies associated with Graves’ disease, SLE, and type I diabetes showed positive findings. We report this case with literatures review.
- A Case of Adrenal Tuberculosis with Atypical Clinical Manifestation
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Moo Hyun Son, Jung Kyu Park, Hyun Sik Hwang, Byung Ho Kim, Eui Dal Jung, Young Sik Choi
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Kosin Med J. 2013;28(2):183-186. Published online January 19, 2013
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DOI: https://doi.org/10.7180/kmj.2013.28.2.183
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Abstract
PDFPubReader ePub
Addison’s disease is a rare disorder that causes fatigue, genral weakness, weight loss, pigmentation due to adrenal hypofunction and it’s underlying causes are various. We report a case of 42-year-old man with fatigue, generalized cutaneous pigmentation. Computed tomography showed bilateral adrenal enlargement, but no calcification. Adrenal tuberculosis was established by ultrasound-guided fine needle aspiration biopsy.
- Expression of Cathpsin B in the Papillary Thyroid Microcarcinoma
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Jae Hong Yang, Young Sik Choi, Yo Han Park, Woo Mi Kim, Jeong Hun Kim, Young Ok Kim
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Kosin Med J. 2009;24(2):153-158. Published online December 31, 2009
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- A Cases of Chronic Hashimoto's Thyroiditis Associated with Hemiagenesis of Thyroid Gland
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Hyun Joo Jung, Ye Na Kim, Young Sik Choi, Yo Han Park
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Kosin Med J. 2009;24(1):154-156. Published online June 30, 2009
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- A Case of Diffuse Sclerosing Variant of Papillary Carcinoma
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Jung Min Choi, Song Ju Lee, Bu Kyung Kim, young Sik Choi, Yo Han Park, Jun Hun Kim, Bang Hur
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Kosin Med J. 2009;24(1):157-160. Published online June 30, 2009
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- A Case of PTEN Gene Mutations Associated with Cowden's Disease
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Sung Jin Nam, Young Sik Choi, Yo Han Park, Kyu Jong Kim, Seun Ja Park
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Kosin Med J. 2008;23(4):239-242. Published online December 31, 2008
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- A Case of Metastatic Small Cell Lung Carcinoma to the Thyroid Gland
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Lee La Jang, Young Sik Choi, Yo Han Park, Dae Sung Moon, Ja Kyung Kim, Sung Eun Kim, In Soo Choi, Chan Hee Yoo, Sung Jin Nam
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Kosin Med J. 2008;23(3):118-121. Published online September 30, 2008
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- A Case of Mixed Medullary and Papillary Carcinoma of the Thyroid
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Jin Woo Koh, Do Hyeong Kim, Mi Kyoung Kim, Hyeon Ok Kim, Young Sik Choi
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Kosin Med J. 2007;22(2):142-146. Published online December 31, 2007
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- A Case of Papillary Thyroid Carcinoma Associated with Familial Adenomatous Polyposis
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Jong Hyun Paek, Chang Bae Sohn, Eun Young Lee, Jee Suk Lee, Eun Kyung Shin, Eun Ho Park, Jeong Ah Seo, Jae Hong Yang, Jun Young Song, Seon Ja Park, Yo Han Park, Young Sik Choi
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Kosin Med J. 2007;22(2):147-150. Published online December 31, 2007
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- A Case of Fulminant Type 1 Diabetes
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Dong Hyeon Rho, Do Hyeong Kim, Na Rae Kim, Jong Sun Park, Chang Hun Lee, Mi Kyoung Kim, Young Sik Choi
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Kosin Med J. 2007;22(2):191-194. Published online December 31, 2007
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- Apoptosis by Cyanate in Kidney Mesangial Cell
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Ji Yeol Kim, Yang Soo Kim, Ki Yeon Hong, Wan Kyu Eo, Young Sik Choi
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Kosin Med J. 2007;22(1):160-169. Published online June 30, 2007
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- The Relationship Between Initial Biochemical Bone Markers and Change of Bone Mineral Density in Post Menopausal Women with Hormone Therapy
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Chi Heui Cho, Eun Hee Kong, Young Sik Choi, Yang Soo Kim, Heung Yeol Kim, Wan Kyu Eo, Ki Yeon Hong
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Kosin Med J. 2007;22(1):212-219. Published online June 30, 2007
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- A case of Thyroid Abscess by Streptococcus intermedius
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Jae Hyun Kim, Young Sik Choi, Yo Han Park, Jung Hun Kim
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Kosin Med J. 2007;22(1):279-282. Published online June 30, 2007
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- Significance of MAGE Common Primers Detecting MAGE 1-6 mRNA in Thyroid Cancers
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Chul Woo Nam, Young Sik Choi, Yo Han Park, Kang Dae Lee
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Kosin Med J. 2006;21(2):20-29.
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- The Effect of Bone in Primary Osteoporosis Treatment of Bisphosphonate
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Young Lim Oh, WAN KYU EO, Young Sik Choi, HEUNG YEOL KIM
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Kosin Med J. 2006;21(2):37-40.
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- Gastric Volvulus as a Complication of a Left Superior Pulmonary Lobectomy
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Sang Ryul Chung, Tae In Ha, Seung Soo Moon, Eun A Lee, Soo Hyoung Lee, Byung Do Chai, Young Sik Choi, Hark Rim
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Kosin Med J. 2006;21(2):175-179.
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- A Case of Acute Myocardial Infarction Managed by 7,920 Joules Shock
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Tae In Ha, Sang Ryul Chung, Sung Soo Moon, Soo Hyoung Lee, Eun Ah Lee, Young Sik Choi
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Kosin Med J. 2006;21(1):13-18.
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- The Relationship between Gamma-Glutamyltransferase and Metabolic Syndrome in the Non Alcoholic Health Screen Examinees
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Ji Eun Park, Nang Hee Kim, Ji Hyun Nam, Ju Hun Kim, Jung Pil Park, Young Sik Choi, Yo Han Park, Jin Ha Kim
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Kosin Med J. 2005;20(1):38-45.
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- A Case of cryptococcal meningitis in an AIDS patient
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Jong Ha Kim, Tae In Ha, Sang Ryul Chung, Young Sik Choi
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Kosin Med J. 2005;20(1):46-48.
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- A Case of Trichuris trichiura Infection with Colonic Inflammation
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Hyo Jin Jung, Jong In Chai, Weol Yong Choi, Kyoung Min Kim, Jong Han Kim, Yong Mok Bae, Jeong Ho Heo, Young Sik Choi
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Kosin Med J. 2004;19(1):258-261.
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- A Case of Teratoma at Neck Midline
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Weol Yong Choi, Hyo Jin Jung, Jong In Chai, Tae In Ha, Sang Ryul Chung, Kwang Jae Lee, Byung Do Chai, Young Sik Choi
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Kosin Med J. 2004;19(1):254-257.
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- Analysis of the ultrasonographic parameters in predicting thyroid cancer
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Hyun Jung Lim, Young Sik Choi, Yo Han Park, Kyung Seung Oh, Kang Dae Lee
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Kosin Med J. 2004;19(1):133-140.
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- A Case of WDHA(Watery diarrhea, Hypokalemia, Achlorhydria) syndrome
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Ki Ryong Park, Hyun Young Kim, Ji Hae Kim, Young Chan Lim, Young Sik Choi, Yo Han Park, Kyung Hyun Choi, Jae Hwa Lee, Hee Kyung Chang
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Kosin Med J. 2003;18(1):22-26.
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- A Case of Pheochromocytoma Accompanied with Hemoptysis
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Yeon Soon Jung, Jin Gu Kim, Soo Keun Song, Su Kyung Kwon, Young Sik Choi, Tae Won Jang, Man Hong Jung, Hee Kung Chang, Jong Chul Kim
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Kosin Med J. 2000;15(1):103-107.
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- A Case of Graves' Disease Associated with Recurrent Myasthenia Gravis
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Dong Hyun Lim, Suk Yung Kwon, Sang Jung Kang, Jin Ku Kim, Young Sik Choi, Yo Han Park, Kwang Soo Kim, Hee Kyung Chang
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Kosin Med J. 2000;15(1):98-102.
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- The Thyroid Cancer in Graves' Disease
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Su Kyung Kwon, Dong Hyun Lim, Sang Jung Kang, Seong Man Kim, Young Sik Choi, Yo Han Park
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Kosin Med J. 2000;15(1):78-83.
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- Relationship of Body Fat Distribution with Metabolic Risk Factors
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Se Jin oh, Sang Jung Kang, Soo Keun Song, Dong Hyun Lim, Seong Man Kim, Young Sik Choi, Yo Han Park, Hyung Soo Cha
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Kosin Med J. 2000;15(1):39-48.
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- A Case of Small Sized Primary Malignant Lymphoma of the Thyroid
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Dal Soo Park, Jin Hyung Lim, Jun Chul Pyun, Young Soo Lee, Young Sik Choi, Yo Han Park, Joong Kyou Kim, Hee Kyung Chang
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The Journal of Kosin Medical College. 1998;13(1-2):45-51.
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- Metastatic pheochrmocytoma : 1 case
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Joong Kyou Kim, Seoung Yeol Kim, Kyung Heon Choi, Young Sik Choi, Ha Yong Yum
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The Journal of Kosin Medical College. 1997;12(1-2):35-40.
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- A Study on the Change of Glucose Metabolism after Gastrectomy
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Young Sik Choi, Yong Ho Ko, Yo-Han Park
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The Journal of Kosin Medical College. 1996;11(1-2):75-84.
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